1 gram of the drug.
contains the active substances
Oxyclozanid – 600 mg,
Abamectin – 6 mg.
The drug Oxyclozanid-600 tablets has a pronounced trematodocidal action, detrimental to all phases of development of Moniezia, Fasciola spp., Paramphistomum spp. and Dicrocoelium lanceatum.
Mechanism of action of oxyclozanide consists in disruption of phosphorylation processes in helminthes, reduction of fumaratreductase and succinate dehydroginase activity, which leads to paralysis and death of trematodes.
Abamectin (avermectin B1), which is a part of the drug, acts detrimentally on larval and sexually mature phases of development of nematodes of lungs, gastrointestinal tract and eyes, larvae of subcutaneous, nasopharyngeal and gastric gadfly, lice, blood suckers and sarcoptoid mites.
Its mechanism of action is to influence the magnitude of chlorine ions current through the membranes of nerve and muscle cells of parasites.
The main targets are glutamate-sensitive chlorine channels as well as gamma-aminobutyric acid (GABA) receptors. Changing the chlorine ion current disrupts nerve impulse conduction, which leads to paralysis and death of parasites.
When administered orally Oxyclozanid-600 tablets are quickly absorbed in the gastrointestinal tract and penetrate into organs and tissues; from the body is excreted mainly with urine and feces.
The drug is prescribed for deworming of cattle, sheep and goats during acute and chronic fascioleosis, moniziosis, dicrocelliosis and paramphistomosis, nematodosis.
Dosage and method of administration:
For therapeutic and preventive purposes the drug shall be administered once in mixture with feed to cattle individually, to small cattle individually or in groups, in the following doses:
cattle in case of paramphistomosis – 1 tablet per 88lb (40 kg) of animal body weight, in case of fasciolosis – 1 tablet per 132lb (60 kg) of animal body weight;
sheep, goats – 15 mg oxyclozanide per 2.2lb (1 kg) of body weight, incl:
lambs up to 33lb (15 kg) – ¼ tablet, sheep from 15 to 30 kg – ½ tablet, sheep, rams over 66lb (30 kg) – 1 tablet.
Deworming of animals against mature trematodes shall be carried out in November-December, against immature trematodes – as indicated.
Special diet and use of laxatives before deworming is not required.
Side effects and complications when using the drug according to these instructions, as a rule, are not observed.
In rare cases after drug administration individual reactions (depression, increased salivation, diarrhea) are possible in animals, which spontaneously disappear and do not require application of drugs.
Slaughter of animals for meat shall be allowed not earlier than 14 days after deworming.
In case of forced slaughter before the deadline, the meat can be used as feed for fur animals or for processing into meat and bone meal.
Milk of milking animals may not be used for food purposes within one day after deworming. Milk obtained earlier than the specified period may be used after boiling in animal feed.
In manufacturer’s packaging, in a dry, dark and out of reach of children, separate from food and feed at 32-77F (0°C to 25°C).
Shelf life: – 3 years.