1000 grams ( Tiamulin 450 ) oral powder of pig, chicken, turkey dysentery, in respiratory diseases, Tiagard, Denagard

Description

CONTACTS

1 gram of the product contains

the active ingredient:

Tiamulin hydrogen fumarate – 450 mg.

 

PHARMACOLOGICAL PROPERTIES

Tiamulin is a semi-synthetic antibiotic belonging to the plevromutilin group.
The drug is active against Gram-positive and Gram-negative microorganisms (Brachyspira innocens, Brachyspira pilosicoli, Leptospira spp., Clostridium perfringens, Streptococcus spp., Starsulloccus spp.., Erysipelothrix rhusiopathiae, Listeria monocytogenes, Pasteurella multocida, Actinomyces pyogenes, Actinobacillus spp., Fusobacterium spp., Klebsiella pneumoniae, Haemophilus spp., Bacteroides spp.., Campylobacter coli, Lawsonia intracellularis) and chlamydia and mycoplasm (Mycoplasma hyopneumoniae, Mycoplasma hyosynoviae, M. hyorhinis, M. bovis, etc.).

Tiamulin acts at 70S-ribosome level, the main binding site is at 50S-sublevel, and the secondary site is possible at 50S and 30S sublevel. It inhibits protein synthesis by microbes, creating biochemical inactive initiative complexes that prevent the growth of polypeptide chain.

In animals and birds, the preparation is in antibacterial concentrations for 18-24 hours.
Tiamulin reaches its maximum concentration in poultry in 2 hours, and in pigs – in 4 hours after inward application.
It is isolated from the body mainly with faeces.

 

TARGET ANIMALS

poultry, pigs,

 

 

APPLICATION INSTRUCTIONS

Treatment of pigs in dysentery, as well as diseases of the respiratory system and joints caused by microorganisms sensitive to tiamulin.

Poultry (broilers, young birds, laying hens, turkeys and turkeys): Treatment of poultry in respiratory diseases caused by microorganisms sensitive to tiamulin.

 

 

ROUTE OF ADMINISTRATION AND DOSAGE

Oral with drinking water or food.
Pigs – for the treatment of dysentery, the dose is – 0.02 grams (8.8 mg thiamulin) per 2.2lb (1 kg) of animal body weight per day for 3-5 days, depending on the severity and duration of the infectious disease. The dose is provided with thiamulin concentration in drinking water of 0.006%;

when treating pigs with respiratory diseases caused by M. hyopneumoniae, P. multocida, the dose is 0.033-0.044 g of the preparation (15.0-20.0 mg thiamulin) per 2.2lb (1 kg) of animal body weight per day for 5-10 days. The dose is provided at concentration of tiamulin in drinking water of 0,012 %-0,018 %;

for the treatment of pleuropneumoniae caused by A.pleuropneumoniae, the dose is 0.044 grams of the preparation (20.0 mg thiamulin) per 2.2lb (1 kg) body weight per day for 5-7 days. The dose is provided at concentration of tiamulin in drinking water 0,018 %;

for pigs with mycoplasma hyosynoviae caused by mycoplasma arthritis, the dose is 0.044 grams (20.0 mg tiamulin) per 2.2lb (1 kg) body weight per day for 5-7 days. The dose is provided at concentration of thiamulin in drinking water 0,018 %.

For preparation of working solutions of necessary tiamulin concentrations it is necessary to dissolve the preparation in drinking water according to the calculations given in Table 1.

 

Table 1.

 

 

Table 2.

 

Turkeys – for treatment of infectious sinusitis and alveolar sacculitis caused by M. gallisepticum, M. synoviae iM. meleagridis orally with drinking water at 0.025% tiamulin concentration in drinking water for 3-5 days.

Depending on poultry age, the daily dose of tiamulin at a concentration of 0.025% in drinking water is:

1-week bird – 0.16 grams of the preparation (70 mg thiamulin) per 2.2lb (1kg) body weight;

2-4 week birds – 0.11 grams of the preparation (50 mg thiamulin) per 2.2lb (1kg) body weight;

5-8 week birds – 0.055-0.07 grams of the preparation (25-30 mg thiamulin) per 2.2lb (1kg) body weight;

90-20-weekly birds – 0.044 grams of the preparation (20 mg thiamulin) per 2.2lb (1 kg) body weight.

HATCHING PERIOD

It is allowed to slaughter animals and poultry for meat in 4 days (pigs), 2 days (broilers, young poultry, laying hens and breeding poultry) and 5 days (turkeys) respectively after the last application of the preparation. The meat received before this period is disposed of or fed to non-productive animals, depending on the conclusion of the veterinary medicine doctor. There is no period of egg cartridges.

Shelf life -3 years.

Shelf life after the first opening (selection): 28 days, provided that it is stored in the original manufacturer’s package in a dry, dark place inaccessible to children at temperatures between 40-77F (5 ° to 25 ° C).

Shelf life after dilution in drinking water – 24 hours.

STORAGE CONDITIONS
Store in the manufacturer’s original packaging in a dark, inaccessible place for children at temperatures between 40-77F (5°C to 25°C).