20ml ( Medetomidine hydrochloride ) Dogs, Cats, Horses for Sedation and Analgesia in exams, minor surgeries and diagnostic manipulations, analog Domitor®,Sedator®

$114,90 $88,90




2 packs 10 ml + 10 ml = 20 ml


The liquid is colorless, transparent.



1 ml of the preparation contains:

Medetomidine hydrochloride – 1 mg.



Pharmacological properties

Medetomidin is a highly selective broad-spectrum alpha-2-adrenor receptor antagonist. It has strong central and peripheral sympatholytic action – reduces release of noradrenaline from the end of sympathetic nerves. Sedative effect is caused by inhibition of blue spot excitation, the main noradrenergic nucleus in brain stem. Acting on this area, medetomidin shows a sedative effect, the strength of which depends on the dose: small doses give a moderate sedative effect without analgesia, large – expressed sedative effect with analgesia.

Medetomidine causes typical hemodynamic changes mediated by alpha-2-adrenor receptors such as bradycardia and arterial hypotension or hypertension. At low doses it reduces heart rate and blood pressure, and at high doses it has a vasoconstrictive effect. At slow infusion, it reduces heart rate and blood pressure, and at rapid injection, it activates the extra-synaptic alpha-2-adrenor receptors of peripheral vessels, resulting in peripheral vasoconstriction effects, while bradycardia becomes more pronounced.

After intramuscular injection is quickly absorbed and distributed in the body, the maximum concentration in the blood is reached after 15-30 minutes. Blood plasma proteins are bound to 85-90%. It is oxidized in the liver, a small part is methylated in the kidneys. Most metabolites are excreted in the urine. The half-life period is 1-2 hours.





The drug is used:

Dogs – for sedation and analgesia during examinations, diagnostic, prophylactic and therapeutic manipulations, for premedication before general anesthesia, general anesthesia with propofol or ketamine, as a sedative and analgesic agent (in combination with butorphanol);

Cats – for sedation, induction of general anesthesia in surgical procedures (in combination with ketamine), sedation and analgesia (in combination with butorphanol), general anesthesia (in combination with butorphanol and ketamine);

Sports horses – for sedation and analgesia in exams, minor surgical interventions and diagnostic manipulations, premedication in injection or inhalation anesthesia.


How to use and doses

The drug is given to dogs intravenously, intramuscularly or subcutaneously, cats – intramuscularly or subcutaneously, horses – intravenously.

The fastest action is after an intravenous injection.

To prolong the sedative and analgesic effect in 10-15 minutes the drug can be injected again.


Doses of the drug for different types are shown in the table.

Animal species Method of administration Purpose of application Drug dose, ml / 22lb (10 kg) of body weight
Dogs i / v, i / m, s / c light sedation 0.1-0.3
medium to deep sedation 0.3-0.8
premedication 0.1-0.2
Cats i / m, s / c medium sedation 0.4-0.8
deep sedation 0.8-1
premedication 0.1-0.3
Horses i / v light sedation 0.2-0.4
medium to deep sedation 0.4-0.8



The dosage of the preparation is chosen according to the required effect, individual features and breed of animal. For small dogs, the dose should be higher than for large dogs.

Maximum effect is achieved in 10-15 minutes, the drug action lasts 0.5-1.5 hours. To prolong it, the drug can be injected again.

12 hours before anesthesia, it is recommended to transfer the animal to a hungry diet.

For premedication, the drug is injected intravenously in 10 minutes, intramuscular – in 20 minutes. The drug should be injected slowly for 30-45 seconds.

Overdose leads to a slow awakening of the animal after anesthesia (sedation).





Do not prescribe to animals with hypersensitivity to the drug, diseases of the cardiovascular and respiratory systems, liver and kidney function disorders, animals in shock, pregnant, lactating, exhausted and weakened animals.

Do not use together with amines, which have a sympathetic effect and anticholinergic drugs.

Do not prescribe puppies under 12 weeks and productive animals.



Storage conditions

In a dry, dark, inaccessible for children place at a temperature from 46-77F (+8 to +25 ° C).

After opening the bottle, store the preparation in the refrigerator and use it for 30 days.



Shelf life

From the date of manufacture – 2 years.



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