Antisedan 10 ml
In 1 ml of the active
Atipamezole hydrochloride – 5 mg
Pharmacological properties :
The active substance atipamezole selectively blocks apha2-adrenoreceptors, resulting in the elimination of the sedative effect of medetomidine , alpha2-adrenoreceptor stimulator.
The maximum concentration of the active substance in the blood is reached after 10-15 minutes.
Atipamezole is oxidized mainly in the liver, a smaller part is methylated in the kidneys.
It is excreted mainly with urine in the form of metabolites.
Half-life period is 1 hour.
Indications for use :
Elimination of sedative and analgesic effects (medetomidine) in dogs and cats, and when it is necessary to eliminate the side effects of medetomidine on the cardiovascular and respiratory systems.
Antisedan not administered to pregnant animals, do not use to eliminate the effects of other sedatives.
Dosage and administration:
The drug is administered intramuscularly once, 15-60 minutes after medetomidine .
The sedative effect of medetomidine is usually relieved within 5-10 minutes.
If necessary, it is possible to re-inject antisedator after 10-15 minutes.
For dogs the dose of antisedan in ml is equal to the dose of medetomidine . For cats, the dose of antisedan in ml is equal to half the administered dose of medetomidine .
Side effects :
Hypotension is noted in dogs after injection during the first 10 minutes.
In rare cases vomiting, rapid breathing, involuntary defecation, short-term shortness of breath and muscle tremors may occur.
In cats, when administered Antisedan may develop the usual hypothermia after anesthesia.
Special Notes :
Due to the strong pharmacological action of Atipamezole it is necessary to avoid contact of Antisedan solution with skin and mucous membranes.
In case of contact of the drug with skin or mucous membranes the place of contact should be immediately rinsed with plenty of water.
Conditions of storage:
With caution , in closed packaging of the manufacturer, in a dry, protected from direct sunlight, out of the reach of children and animals.
Separated from food and feed at a temperature of 59-77F (15 C to 25 C).
Shelf life – 3 years from the date of manufacture, after opening the bottle – no more than 4 weeks (28 days).