Liquid of light yellow color, transparent, sterile.
1 ml of the drug contains:
Imidocarb Dipropionate – 120 mg
Pharmacological properties :
Imidocarb dipropionate, a derivative of Icarbanilide, provides a broad spectrum of antiprotozoal action against pyroplasmidosis pathogens in mono- or mixed infestations – Babesia bovis, B. bigemina, B. colchis (Francaiella colchica), B. divergens, B. ovis, B. motasi, B. caballi, B. eqi (Nuttallia equi), B. canis, B. gibsonii, B. vogeli, Theileria annulata, T. sergenti, T. mutans, T. orientalis, T. ovis, T. recondita, T. hirci, T. tarandirangiferis, rickettsiae of the genera Anaplasma marginale, A. centrale, A. ovis, A. phagocytophilum, and the genera Ehrlichia canis, E. chaffeensis.
Mechanism of antiprotozoal action is based on inhibition of aerobic glucose metabolism and DNA synthesis in pyroplasmids, which causes their further death.
After parenteral administration the drug is quickly absorbed and reaches maximum concentration in blood after 1-2 hours, therapeutic concentration is maintained for 4-6 weeks.
It is metabolized to a small extent, accumulates mainly in kidneys and liver, is eliminated from the body mainly with feces, to a lesser extent with urine.
Imidokarba dipropionate refers to moderately hazardous substances according to the degree of impact on the body.
How to use and dosages :
Shake drug vial thoroughly before use and apply:
Cattle, buffalo, zebu, camels: subcutaneously, once, the dose per 220lb (100 kg) of body weight is: babesiosis – 2 ml, anaplasmosis, mixed infestations – 2.5 ml, prophylaxis – 2 ml;
Sheep, goats, mouflons, fallow deer: babesiosis, anaplasmosis – 0.2 ml per 10 kg of body weight, intramuscularly or subcutaneously, once
Horses, mules, donkeys: intramuscularly, the dose per 220lb (100 kg) of body weight is: Babesia caballi – 2 ml, course – 2 injections every 24 hours, Babesia equi – 3 ml, course – 4 injections every 3 days;
In dogs: Babesiosis – 0.3-0.5 ml per 22lb (10 kg) of body weight (subcutaneously, once), if necessary, repeat in 14 days in dose 0.2 ml.
In case of group housing of animals and detection of blood-parasitic diseases the drug shall be administered to all livestock in preventive dose, in cattle the injection shall be repeated in 6 weeks, in animals of other species – in 4 weeks. The protective effect of the drug lasts for 14-21 days after its administration.
Recommended doses do not cause local irritation, does not exhibit cumulative, embryotoxic and mutagenic properties.
However, in case of mass death of parasites and destruction of red blood cells in animals, intoxication is possible. In such cases intensive therapy with infusion agents, hepatoprotectors, symptomatic and antihistamines is required.
To avoid painful reaction, do not inject more than 10 ml of the drug in one place in large animals, more than 2 ml in small ones.
In case of clinical signs of babesiosis before drug administration it is advisable to use antihistamines.
After the last drug administration slaughter of cattle, horses and sheep for meat shall be allowed after 110 days, milk may be consumed in humans after 7 days.
Meat obtained before the specified period shall be fed to fur-bearing animals, milk after boiling shall be given to animals. Milk of milking sheep injected with the drug at least once is prohibited for human consumption!
Treatment and prophylaxis of cloven-hoofed ruminants (cattle, buffalo, sheep, goats, zebu, mouflon, fallow deer, camels) against babesiosis, teileriosis, anaplasmosis and mixed invasions; unpaired farm animals (horses, mules, donkeys) – for babesiosis, anaplasmosis and mixed infestations; dogs – for acute, chronic, subclinical and atypical babesiosis, ehrlichiosis, anaplasmosis and mixed infestations.
Chemoprophylaxis of babesiosis – administration of the drug immediately after detection of imbedded tick and in animals of risk group (hunting dogs).
Do not administer to animals sensitive to the drug’s active substance.
Do not use simultaneously with organochlorine and organophosphorus drugs and cholinesterase inhibitors.
Do not use within 4 weeks after vaccination with live vaccine against babesiosis or anaplasmosis.
Storage Conditions :
Store in a dry, ventilated place, protected from direct sunlight, out of reach of children and animals, away from food and feed at 40-77 F (+5 to +25 °С).
After opening the bottle, keep the drug in refrigerator and use within 30 days.
Shelf life is – 2 years.