Description
Tablets are light brown, oval-shaped, flat.
Composition :
7.5 grams of the drug.
(1 tablet) contains:
Sulfadiazine sodium salt – 3975 mg
Kanamycin sulfate – 50.25 mg
Oxytetracycline hydrochloride – 50.25 mg
Application :
Treatment and prevention of cows for acute endometritis, metritis, cervicitis, vulvovaginitis caused by Gram-positive, Gram-negative, aerobic and anaerobic bacteria – A. pyogenes, Streptococcus spp., Staphylococcus aureus, E. coli, Proteus spp., Klebsiella spp. etc.
Sanitation of the uterus after removal of the delayed placenta.
Pharmacological properties :
A complex drug with a broad spectrum of antibacterial action.
Sulfadiazine belongs to sulfonamides due to its structural similarity with para-aminobenzoic acid; it inhibits the bacterial enzyme responsible for biosynthesis of dihydrofolic acid, which is the precursor of folic acid in the bacterial cell.
Oxytetracycline hydrochloride inhibits the activity of bacterial ribosomes and leads to disruption of protein synthesis. A number of metabolic processes in the microbial cell are inhibited due to the formation of chelated compounds with divalent metal cations.
Kanamycin sulfate refers to aminoglycoside antibiotics, penetrates through the cell membrane and irreversibly binds to specific receptor proteins on the 30S subunits of ribosomes. Disrupts the formation of a complex between matrix (informational) RNA and the 30S subunit of the ribosome, which causes biosynthesis of inferior proteins in the cell, disintegration of polyribosomes and loss of the ability to synthesize protein. Disrupts the structure and function of cytoplasmic membranes and causes rapid death of the microbial cell.
Auxiliary foaming constituents ensure distribution of the drug throughout the uterine cavity and complete contact of the antibiotic with the mucosa.
Directions for use and dosages:
It is administered to cows inside the uterus in the following doses:
Prophylaxis – 7.5-10 g during the first day after calving, once;
Treatment – 12.5-15 grams, course – 2-3 days (until closure of the cervix).
Cautions :
Side effects are usually not observed when used in the indicated doses. Allergic reactions are possible in hypersensitive animals.
After the last drug administration slaughter of animals for meat is allowed after 2 days.
Meat obtained earlier than specified period may be used only for production of meat and bone meal.
People can eat milk after 2 days, until this time it is fed to animals after heat treatment.
Translated with www.DeepL.com/Translator (free version)
Contraindications :
Do not prescribe an animal with hypersensitivity to the active substances of the drug.
Conditions of storage:
In a dry, dark, out of reach of children at a temperature of 39-77 F (+4 to +25 ° C).
Shelf life – 3 years.
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