contains 1 gram of the preparation:
Doxycycline giclate – 200 mg;
Colistin – 2 400 000 IU.
Powder of light yellow or yellow color.
Pharmacological properties :
Doxycycline is a semi-synthetic antibiotic of the second generation tetracyclines group. It penetrates through the lipid barrier of bacteria, binds to 30S subunits, blocks the interaction between aminoacyl tRNA and matrix mRNA, and inhibits the synthesis of microbial cell proteins. It has a wide range of antimicrobial action on Gram-positive and Gram-negative bacteria Staphylococcus spp., Diplococcus pneumoniae, Streptococcus spp., Erysipelothrix spp., Haemophilus spp.., Escherichia coli, Bacillus antracis, Clostridium tetani, Clostridium perfringes, Listeria spp., Pasteurella spp., Bordetella bronchiseptica, Eptetebaster spp., Brucella spp, Klebsiella spp., Salmonella spp., Shigella spp., Yersinia spp., Campylobacter spp., Mycoplasma spp., Rickettsia spp., Chlamydia spp.
Unlike other antibiotics of tetracycline series, less depresses intestinal microflora, is better absorbed, acts longer and stronger. It gives the chance to lower a dose in 5-10 times.
When used orally, bioavailability is more than 90%, for birds – up to 100%. It penetrates almost all organs and tissues, the maximum concentration is observed in the lungs, liver, bile, reproductive organs and kidneys. At a dose less than the therapeutic level penetrates into the CMW. The maximum concentration in blood of most animals is registered in 2-4 hours, in broilers – in 1.3-1.4 hours and is kept at the therapeutic level for 18-24 hours.
Half-life period for cattle – 6-19 hours, pigs – 7 hours, broilers – 13-17 hours. It is mainly bred in unchanged form, mainly with bile.
Colistin is a polypeptide antibiotic of a group of polymixins, which is synthesized by aerobic spore-forming Bacillus polymyxa stick. It acts bactericidally mainly on E. coli, Salmonella spp., Pseudomonas spp., Pasteurella spp., Haemophilus spp., Klebsiella spp., Shigella spp., Bordetella spp. It binds to the phospholipids of the cytoplasmic membrane, increases its permeability for both internal and external components of the cell, which leads to destruction of the bacterial cell. It binds phospholipid A and neutralizes the action of bacterial endotoxin.
Due to its polypeptide structure, it is practically not absorbed through the gastrointestinal walls and is effective only in case of bacterial diseases of the gastrointestinal organs. It is excreted from the body mainly with feces, in small amounts – with urine (when used in very large doses).
Treatment of calves, lambs, goats up to 2 months old, pigs, poultry (chickens-broilers, repair youngsters, turkeys) in case of gastrointestinal and respiratory diseases caused by microorganisms sensitive to the active substances of the preparation.
How to use and doses :
Before each use, the drug is mixed with drinking water or feed, the course – 4-5 days. Doses are made:
– calves, lambs, goats under 2 months old – 0.25 grams per 22lb (10 kg) body weight, 2 times a day with water, feed, milk or its substitute;
– pigs – 0.2 grams per 22lb (10 kg) body weight or 500 grams per 1000 liters of water or 1100lb (500 kg) feed;
– poultry (broilers, repair youngsters, turkeys) under 2 months of age – 0.1 grams per 22lb (10 kg) body weight or 250 grams per 1000 liters of water;
– poultry (repair youngsters, turkeys) older than 2 months – 0.2 grams per 22lb (10 kg) body weight or 500 grams per 1000 liters of water.
The personnel who come into contact with the preparation must observe the rules of hygiene and safety adopted when working with veterinary medicines.
After the last application of the preparation poultry slaughter for meat is allowed in 7 days, pigs – in 8 days, calves, lambs, goats – in 14 days.
Meat, received earlier than this period, is disposed or fed to unproductive animals, depending on the conclusion of the veterinary doctor.
Do not prescribe to animals with hypersensitivity to tetracyclines and polymixins, with severe liver and kidney dysfunction, laying hens, eggs which are eaten by people, ruminants with functionally developed stomachs.
Do not use simultaneously with penicillins, cephalosporins, quinolones, as well as with cycloserine, sodium bicarbonate, preparations containing iron, aluminum, magnesium, as the latter impair its absorption.
Storage conditions :
In a dry, dark place, inaccessible to children at temperatures between 59-77F (+15 to +25 ° C).
After opening the bottle, the preparation should be used within 14 days, the solution of the preparation – within a day, the mixture with food – within 30 days.
Shelf life : – 2 years.