1 ml of the drug contains :
Progesterone – 150 mg
Pharmacological properties :
Progesterone belongs to the pharmacological group: hormones and their antagonists.
During subcutaneous or intramuscular administration of the drug, the required exogenous level of progesterone in blood to exhibit therapeutic action is maintained for 6-7 days, but does not exceed the physiological content in animals.
Progesterone inhibits hypothalamo-pituitary system, as a consequence there is no release of gonadotropic hormones – follicle stimulating and luteinizing, as a result there is no follicle maturation and ovulation.
Upon termination of the drug, spontaneous secretion of gonadotropic hormones occurs, which leads to follicle maturation and ovulation.
Progesterone metabolism occurs in the liver. Progesterone metabolites excreted from animals are biologically inactive.
For the treatment of ovarian hypofunction in cows;
For the prevention of abortion and early embryonic death;
For synchronization of libido in cows and heifers.
For synchronization of libido in cows and heifers Progesterone is administered once subcutaneously or intramuscularly at a dose of 10 ml/head regardless of the stage of the sexual cycle. After 7 days, the animal shall be injected with cloprostenol in a dose of 2 ml/head (500 µg cloprostenol) per animal. Animals come into hunt 36-96 hours after cloprostenol administration, the majority of cows and heifers come into hunt after 72 hours.
For treatment of ovarian hypofunction in cows and heifers, Progesterone shall be administered once in a single p/k or v/m dose of 10 ml, after 7 days, cloprostenol shall be administered simultaneously in different sides of the croup at a dose of 2 ml/head.
Insemination is carried out according to the fact of hunting manifestation, since there is a significant variation in the time of its manifestation in animals.
To prevent early embryonic mortality in cows, Progesterone is injected at a dose of 2 ml per head on days 5, 7, 9 and 14 after insemination.
In order to prevent abortions Progesterone is administered according to indications at a dose of 2 ml/head.
The drug shall be administered usually once.
No peculiarities of action of the drug during its first use and withdrawal have been revealed
The drug should be stored in the manufacturer’s sealed package in a dry place protected from direct sunlight, out of reach of children, away from food and feed, at 40-77 F (5°C to 25°C).
After the first opening of the bottle the drug may be used within 28 days in strict aseptic conditions and stored in refrigerator at temperatures 35-45 F (2 ° C to 8 ° C).
Shelf life is 2 years from the date of manufacture.